Harbor-UCLA Pediatrics

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Henry J. Lin, M.D.

Henry Lin, M.D.

Henry J. Lin, M.D.
Professor of Pediatrics
Division of Medical Genetics

Contact Information:
Child Health Research Center
1124 W. Carson St.
Torrance, CA 90502

Phone: (310) 222-3783
Fax: (310) 328-9921
Email: hlin@labiomed.org

Research Focus:
My research focuses on genetic factors related to the development of intestinal tumors. Our recognized discoveries are: the first large, population genetic study of acetylation (NAT2) mutations; the first gene-diet interaction associated with cancer (GSTM1-sulforaphane); and prostaglandin D2 as a molecule that suppresses intestinal tumors. Our current work is on the role of prostaglandin D2 in suppressing intestinal tumors. The work is relevant to potential approaches for prevention or treatment of familial adenomatous polyposis and sporadic colorectal neoplasia. Clinical activities within the department are focused on the practice of medical genetics.

American Board of Internal Medicine
American Board of Medical Genetics (Clinical Genetics, Clinical Molecular Genetics)

Internship and Residency in Internal Medicine, Harbor-UCLA Medical Center
Fellowship in Medical Genetics, NIH Interinstitute Medical Genetics Training Program

M.D., Harvard Medical School
A.B., Biochemistry, University of California, Berkeley

Selected Publications:

1. Lin HJ, Han CY, Lin BK, Hardy S. Slow acetylator mutations in the human polymorphic N-acetyltransferase gene in 786 Asians, blacks, Hispanics, and whites: Application to metabolic epidemiology. Am J Hum Genet 52:827-834, 1993. 8460648

2. Probst-Hensch NM, Haile RW, Ingles SA, Longnecker MP, Han CY, Lin BK, Lee DB, Sakamoto GT, Frankl HD, Lee ER, Lin HJ. Acetylation polymorphism and prevalence of colorectal adenomas. Cancer Res 55: 2017-2020 (1995). 7743494

3. Lin HJ. Smokers and breast cancer: 'chemical individuality' and cancer predisposition. JAMA 276:1511-1512 (1996). 8903264

4. Lin HJ, French SW, Reichenbach D, Wan Y-J Y, Passaro E Jr, Sawicki MP. Novel p53 mutation in a malignant tumor secreting vasoactive intestinal peptide. Arch Pathol Lab Med 121:125-128 (1997). 9126038

5. Lin HJ, Probst-Hensch NM, Hughes NC, Sakamoto GT, Louie AD, Kau IH, Lin BK, Lee DB, Lin J, Frankl HD, Lee ER, Hardy S, Grant DM, Haile RW. Variants of N-acetyltransferase NAT1 and a case-control study of colorectal adenomas. Pharmacogenetics 8:269-281 (1998). 9682272

6. Lin HJ, Probst-Hensch NM, Louie AD, Kau IH, Witte JS, Ingles SA, Frankl HD, Lee ER, Haile RW. Glutathione transferase null genotype, broccoli, and lower prevalence of colorectal adenomas. Cancer Epidemiol Biomark Prev 7:647-652 (1998). 9718215

7. Macayran JF, Doroshow RW, Phillips J, Sinow RM, Furst BA, Smith LM, Lin HJ. PAGOD syndrome: eighth case and comparison to animal models of congenital vitamin A deficiency. Am J Med Genet 108:229-234 (2002). 11891692

8. Lin HJ, Lakkides KM, Keku TO, Reddy ST, Louie AD, Kau IH, Zhou H, Gim JSY, Ma HL, Matthies CF, Dai A, Huang H-F, Materi AM, Lin JH, Frankl HD, Lee ER, Hardy SI, Herschman HR, Henderson BE, Kolonel LN, Le Marchand L, Garavito RM, Sandler RS, Haile RW, Smith WL. Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia. Cancer Epidemiol Biomark Prev 11:1305-1315 (2002). 12433707

9. Park JM, Kanaoka Y, Eguchi N, Aritake K, Grujic S, Materi AM, Buslon VS, Tippin BL, Kwong AM, Salido E, French SW, Urade Y, Lin HJ. Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice. Cancer Res 67: 881-9 (2007). 17283118

10. Lin HJ, Neidich JA, Salazar D, Thomas-Johnson E, Ferreira BF, Kwong AM, Lin AM, Jonas AJ, Levine S, Lorey F, Rosenblatt DS. Asymptomatic maternal combined homocystinuria and methylmalonic aciduria (cblC) detected through low carnitine levels on newborn screening. J Pediatr 155: 924-7 (2009). 19914430

11. Lin HJ, Kwong AM, Carter JM, Ferreira BF, Austin MF, Devarajan K, Coleman RJ, Feuchtbaum LB, Lorey F, Jonas AJ. Extremely high phenylalanine levels in a newborn on parenteral nutrition: phenylketonuria in the neonatal intensive care unit. J Perinatol 31: 507-10 (2011).

12. Kwong AM*, Tippin BL*, Materi AM, Buslon VS, French SW, Lin HJ. High dietary niacin may increase prostaglandin formation but does not increase tumor formation in ApcMin/+ mice. Nutr Cancer 2011; 63: 950-9. *Contributed equally. 21774590

13. Tippin BL, Levine AL, Materi AM, Song WL, Keku TO, Goodman JE, Sansbury LB, Das S, Dai A, Kwong AM, Lin AM, Lin JM, Park JM, Patterson RE, Chlebowski RT, Garavito RM, Inoue T, Cho W, Lawson JA, Kapoor S, Kolonel LN, Le Marchand L, Haile RW, Sandler RS, Lin HJ. Hematopoietic prostaglandin D synthase (HPGDS): a high stability, Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal cancer. Prostaglandins Other Lipid Mediat 2012; 97: 22-8. 21821144

14. Chang RKR, Lan YT, Silka MJ, Morrow H, Kwong A, Smith-Lang J, Wallerstein R, Lin HJ. Genetic variants for long QT syndrome among infants and children from a statewide newborn hearing screening program cohort. J Pediatr 2014; 164: 590-5. 24388587

15. Lin HJ, Lugo H, Tran T, Tovar JP, Corral J, Zork NM, Smith LM, French SW, Barajas L. A tortuous proximal urethra in urorectal septum malformation sequence? Am J Med Genet A 2014; 164: 1298-303. 24665006

16. Panosyan EH, Wang Y, Xia P, Lee W-NP, Pak Y, Laks DR, Lin HJ, Moore TB, Cloughesy TF, Kornblum HI, Lasky JL III. Asparagine depletion potentiates the cytotoxic effect of chemotherapy against brain tumors. Mol Cancer Res 2014; 12: 694-702. 24505127 PMCID: PMC4020976

17. Tippin BL, Kwong AM, Inadomi MJ, Lee OJ, Park JM, Materi AM, Buslon VS, Lin AM, Kudo LC, Karsten SL, French SW, Narumiya S, Urade Y, Salido E, Lin HJ. Intestinal tumor suppression in ApcMin/+ mice by prostaglandin D2 receptor PTGDR. Cancer Med 2014; in press. 24729479

18. Chou TF, Bulfer SL, Weihl CC, Li K, Lis LG, Walters MA, Schoenen FJ, Lin HJ, Deshaies RJ, Arkin MR. Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. J Mol Biol 2014; in press. 24878061

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