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Rebecca Stockton, Ph.D.

Rebecca Stockton, Ph.D.

Rebecca Stockton, Ph.D.
Assistant Professor of Pediatrics
Division of Medical Genetics

Contact Information:
Child Health Research Center
1124 W. Carson St.
Torrance, CA 90502

Phone: (424) 201-3005
rstockton@ucla.edu

Research Focus:
Dr. Stockton’s laboratory studies the pathophysiology and therapy of cerebral cavernous malformation syndrome and other genetic vascular disorders.

Training:
Senior Postdoctoral Scholar, Div. of Rheumatology, Allergy and Immunology, University of California San Diego School of Medicine
NIH Cardiovascular Postdoctoral Training Fellowship, Cardiovascular
Research Center, University of Virginia Health Sciences Center, Charlottesville, VA
Graduate Research Fellowship, Dept. of Biochemistry and Molecular, Biology, University of Massachusetts Amherst, Amherst, MA

Education:
Ph.D., Molecular and Cellular Biology, University of Massachusetts Amherst
B.Sc., Biology, California State University Bakersfield

Selected Publications:
1. Plummer ST, Wang Q, Bohn PW, Stockton R, Schwartz MA. Electrochemically Derived Gradients of the Extracellular Matrix Protein Fibronectin on Gold. Langmuir, 2003 19(18), 7528-7536.

2. Green JA, Stockton RA, Johnson C, Jacobson BS. 5-lipoxygenase and cyclooxygenase regulate wound closure in NIH/3T3 fibroblast monolayers. Am J Physiol Cell Physiol. 2004 Aug;287(2):C373-83. Epub 2004 Apr 7. PMID: 15197007

3. Stockton RA, Schaefer E, Schwartz MA. p21-activated kinase regulates endothelial permeability through modulation of contractility. J Biol Chem. 2004 Nov 5;279(45):46621-30. Epub 2004 Aug 27. PMID: 15333633

4. Tsai IY, Kimura M, Stockton R, Green JA, Puig R, Jacobson B, Russell TP. Fibroblast adhesion to micro- and nano-heterogeneous topography using diblock copolymers and homopolymers. J Biomed Mater Res A. 2004 Dec 1;71(3):462-9. PMID: 15484209

5. Reutershan J, Stockton R, Zarbock A, Sullivan G W, Chang D, Scott D, Schwartz MA, Ley K. (2006) “Critical Role Of Neutrophil P21-Activated Kinase In LPS-Induced Acute
Lung Injury” , (Intensive Care Med. 32-S13: 14,96)

6. Orr AW, Stockton R, Simmers MB, Sanders JM, Sarembock IJ, Blackman BR, Schwartz MA. Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis. J Cell Biol. 2007 Feb 26;176(5):719-27. Epub 2007 Feb 20. PMID: 17312022

7. Reutershan J, Stockton R, Zarbock A, Sullivan GW, Chang D, Scott D, Schwartz MA, Ley K. Blocking p21-activated kinase reduces lipopolysaccharide-induced acute lung injury by preventing polymorphonuclear leukocyte infiltration. Am J Respir Crit Care Med. 2007 May 15;175(10):1027-35. Epub 2007 Feb 22. PubMed PMID: 17322107

8. Stockton R, Reutershan J, Scott D, Sanders J, Ley K, Schwartz MA. Induction of vascular permeability: beta PIX and GIT1 scaffold the activation of extracellular signal-regulated kinase by PAK. Mol Biol Cell. 2007 Jun;18(6):2346-55. Epub 2007 Apr 11. PMID: 17429073

9. Glading A, Han J, Stockton RA, Ginsberg MH. KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions. J Cell Biol. 2007 Oct 22;179(2):247-54. PMID: 17954608

10. Jones CA, London NR, Chen H, Park KW, Sauvaget D, Stockton RA, Wythe JD, Suh W, Larrieu-Lahargue F, Mukouyama YS, Lindblom P, Seth P, Frias A, Nishiya N, Ginsberg MH, Gerhardt H, Zhang K, Li DY. Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat Med. 2008 Apr;14(4):448-53. Epub 2008 Mar 16. Erratum in: Nat Med. 2008 May;14(5):585. PMID: 18345009

11. Goldfinger LE, Tzima E, Stockton R, Kiosses WB, Kinbara K, Tkachenko E, Gutierrez E, Groisman A, Nguyen P, Chien S, Ginsberg MH. Localized alpha4 integrin phosphorylation directs shear stress-induced endothelial cell alignment. Circ Res. 2008 Jul 18;103(2):177-85. Epub 2008 Jun 26. PMID: 18583710

12. Stockton RA, Shenkar R, Awad IA, Ginsberg MH. Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. J Exp Med. 2010 Apr 12;207(4):881-96. Epub 2010 Mar 22. PMID: 20308363

13. McDonald DA, Shenkar R, Shi C, Stockton RA, Akers AL, Kucherlapati MH, Kucherlapati R, Brainer J, Ginsberg MH, Awad IA, Marchuk DA. A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. Hum Mol Genet. 2011 Jan 15;20(2):211-22. Epub 2010 Oct 11. PMID: 20940147

14. Liu JJ, Stockton RA, Gingras AR, Ablooglu AJ, Han J, Bobkov AA, Ginsberg MH. A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions. Mol Biol Cell. 2011 Jul 15;22(14):2509-19. Epub 2011 Jun 1. PMID: 21633110

15. McDonald DA, Shi C, Shenkar R, Stockton RA, Liu F, Ginsberg MH, Marchuk DA, Awad IA. Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. Stroke. 2012 Feb;43(2):571-4. Epub 2011 Oct 27. PMID: 22034008

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