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Michelina Iacovino, Ph.D.

Michelina Iacovino, Ph.D.

Michelina Iacovino, Ph.D.
Assistant Professor of Pediatrics
Division of Medical Genetics

Contact Information:
Child Health Research Center
1124 W. Carson St.
Torrance, CA 90502

Phone: (310) 222-3751
Email: iacovino@ucla.edu

Research Focus:
Dr. Iacovino's work, funded by a grant from the American Heart Association, centers on hematopoietic stem cell biology, particularly with regard to the development of vascular endothelium and stem cell therapies.

Training:
Postdoctoral fellowship, Department of Pediatrics, The Lillehei Heart Institute, University of Minnesota, Minneapolis, MN
Postdoctoral fellowship, Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX

Education:
Ph.D., Applied Biochemistry and Chemistry, University of Molise, Campobasso, Italy

Selected Publications:

1. Szatmari I, Iacovino M, Kyba M. The retinoid signaling pathway inhibits hematopoiesis and uncouples from the Hox genes during hematopoietic development. Stem Cells. 2010 Sep;28(9):1518-29. PMID: 20681018

2. Mallanna SK, Ormsbee BD, Iacovino M, Gilmore JM, Cox JL, Kyba M, Washburn MP, Rizzino A. Proteomic analysis of Sox2-associated proteins during early stages of mouse embryonic stem cell differentiation identifies Sox21 as a novel regulator of stem cell fate. Stem Cells. 2010 Oct;28(10):1715-27. PMID: 20687156

3. Iacovino M, Chong D, Szatmari I, Hartweck L, Rux D, Caprioli A, Cleaver O, Kyba M. HoxA3 is an apical regulator of haemogenic endothelium. Nat Cell Biol. 2011 Jan;13(1):72-8. Epub 2010 Dec 19. PMID: 21170035

4. Chen C, Chai J, Singh L, Kuo CY, Jin L, Feng T, Marzano S, Galeni S, Zhang N, Iacovino M, Qin L, Hara M, Stein R, Bromberg JS, Kyba M, Ku HT. Characterization of an in vitro differentiation assay for pancreatic-like cell development from murine embryonic stem cells: detailed gene expression analysis. Assay Drug Dev Technol. 2011 Aug;9(4):403-19. doi: 10.1089/adt.2010.0314. Epub 2011 Mar 11. PMID: 21395400

5. Caprioli A*, Koyano-Nakagawa N*, Iacovino M*, Shi X, Ferdous A, Harvey RP, Olson EN, Kyba M, Garry DJ. Nkx2-5 represses Gata1 gene expression and modulates the cellular fate of cardiac progenitors during embryogenesis. Circulation. 2011 Apr 19;123(15):1633-41. Epub 2011 Apr 4. PMID: 21464046 *Co-first author

6. Chalamalasetty RB, Dunty WC Jr, Biris KK, Ajima R, Iacovino M, Beisaw A, Feigenbaum L, Chapman DL, Yoon JK, Kyba M, Yamaguchi TP. The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program. Nat Commun. 2011 Jul 12;2:390. doi: 10.1038/ncomms1381. PMID: 21750544

7. Zhu R, Iacovino M, Mahen E, Kyba M, Matin A. Transcripts that associate with the RNA binding protein, DEAD-END (DND1), in embryonic stem (ES) cells. BMC Mol Biol. 2011 Aug 18;12:37. PMID: 21851623

8. Liebau S, Tischendorf M, Ansorge D, Linta L, Stockmann M, Weidgang C, Iacovino M, Boeckers T, von Wichert G, Kyba M, Kleger A. An inducible expression system of the calcium-activated potassium channel 4 to study the differential impact on embryonic stem cells. Stem Cells Int. 2011;2011:456815. Epub 2011 Sep 15. PMID: 21941566

9. Iacovino M*, Bosnakovski D*, Fey H, Rux D, Bajwa G, Mahen E, Mitanoska A, Xu Z, Kyba M. Inducible cassette exchange: a rapid and efficient system enabling conditional gene expression in embryonic stem and primary cells. Stem Cells. 2011 Oct;29(10):1580-8. PMID: 22039605. *Co-first author.

10. Mazzoni EO, Mahony S, Iacovino M, Morrison CA, Mountoufaris G, Closser M, Whyte WA, Young RA, Kyba M, Gifford DK, Wichterle H. Embryonic stem cell-based mapping of developmental transcriptional programs. Nat Methods. 2011 Nov 13;8(12):1056-8. doi: 10.1038/nmeth.1775. PMID: 22081127

11. Zuo X, Sheng J, Lau HT, McDonald CM, Andrade M, Cullen DE, Bell FT, Iacovino M, Kyba M, Xu G, Li X. Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain. J Biol Chem. 2012 Jan 13;287(3):2107-18. Epub 2011 Dec 5. PMID: 22144682

12. Jain AK, Allton K, Iacovino M, Mahen E, Milczarek RJ, Zwaka TP, Kyba M, Barton MC. p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells. PLoS Biol. 2012 Feb;10(2):e1001268. Epub 2012 Feb 28. PMID: 22389628

13. van den Ameele J, Tiberi L, Bondue A, Paulissen C, Herpoel A, Iacovino M, Kyba M, Blanpain C, Vanderhaeghen P. Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin. EMBO Rep. 2012 Apr;13(4):355-62. PMID: 22402664

14. Borges L, Iacovino M, Mayerhofer T, Koyano-Nakagawa N, Baik J, Garry DJ, Kyba M, Letarte M, Perlingeiro RC. A critical role for endoglin in the emergence of blood during embryonic development. Blood. 2012 Jun 7;119(23):5417-28. Epub 2012 Apr 24. PMID: 22535663

15. Koyano-Nakagawa N, Kweon J, Iacovino M, Shi X, Rasmussen TL, Borges L, Zirbes KM, Li T, Perlingeiro RC, Kyba M, Garry DJ. Etv2 is Expressed in the Yolk Sac Hematopoietic and Endothelial Progenitors and Regulates Lmo2 Gene Expression. Stem Cells. 2012 May 24. doi: 10.1002/stem.1131. [Epub ahead of print] PMID: 22628281

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