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Frans Walther, M.D., Ph.D.

Frans Walther, M.D., Ph.D.

Frans J. Walther, M.D., Ph.D.
Professor of Pediatrics
Division of Medical Genetics

Contact Information:
Phone: (310) 222-8150
Fax: (310) 222-6701
Email: fjwalther@ucla.edu

Research Focus:
Neonatology, physiology, molecular medicine, lung surfactant deficiency, prematurity-related breathing problems, newborn respiratory distress syndrome, intrauterine malnutrition, neonatal and early childhood morbidity, molecular biotechnology research on chronic lung disease, long-term outcomes of very premature infants, neuroimaging of the developing brain, developmental care, ventilation strategies, and autologous cord blood transfusion.

American Board of Pediatrics, Neonatal-Perinatal Medicine

M.D., Leiden University, The Netherlands

Selected Publications:

1. Walther FJ. Is Lung Surfactant Ready 'to Protect and to Serve' in Necrotizing Enterocolitis?. Commentary on F.E. Canpolat et al.: Effects of Enterally Administered Surfactant in a Rat Model of Necrotizing Enterocolitis (Neonatology 2012;102:53-58). Neonatology. 2012 Apr 11;102(1):59-60. [Epub ahead of print] PMID: 22508106

2. Walther FJ. Oral Ibuprofen for Patent Ductus Arteriosus: Effective and Safe or Just Cheap?. Commentary on R. Neumann et al.: Oral Ibuprofen versus Intravenous Ibuprofen or Intravenous Indomethacin for the Treatment of Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-Analysis (Neonatology 2012;102:9-15). Neonatology. 2012 Mar 8;102(1):16-18. [Epub ahead of print] PMID: 22414909

3. de Villiers S, Slaghekke F, Middeldorp JM, Klumper FJ, Walther FJ, Oepkes D, Lopriore E. Arterio-arterial vascular anastomoses in monochorionic twin placentas with and without twin anemia-polycythemia sequence. Placenta. 2012 Mar;33(3):227-9. Epub 2012 Jan 16. PMID: 22257747

4. Lopriore E, Pasman SA, Klumper FJ, Middeldorp JM, Walther FJ, Oepkes D. Placental characteristics in growth-discordant monochorionic twins: a matched case-control study. Placenta. 2012 Mar;33(3):171-4. Epub 2011 Dec 23. PMID: 22197628

5. van Vonderen JJ, Siew ML, Hooper SB, de Boer MA, Walther FJ, Te Pas AB. Effects of naloxone on the breathing pattern of a newborn exposed to maternal opiates. Acta Paediatr. 2012 Feb 28. doi: 10.1111/j.1651-2227.2012.02649.x. [Epub ahead of print] PMID: 22372574

6. Smits-Wintjens VE, Rath ME, Lindenburg IT, Oepkes D, van Zwet EW, Walther FJ, Lopriore E. Cholestasis in Neonates with Red Cell Alloimmune Hemolytic Disease: Incidence, Risk Factors and Outcome. Neonatology. 2012 Feb 18;101(4):306-310. [Epub ahead of print] PMID: 22354012

7. Schilleman K, Siew ML, Lopriore E, Morley CJ, Walther FJ, Te Pas AB. Auditing resuscitation of preterm infants at birth by recording video and physiological parameters. Resuscitation. 2012 Feb 6. [Epub ahead of print] PMID: 22322286

8. Lindenburg IT, Smits-Wintjens VE, van Klink JM, Verduin E, van Kamp IL, Walther FJ, Schonewille H, Doxiadis II, Kanhai HH, van Lith JM, van Zwet EW, Oepkes D, Brand A, Lopriore E; LOTUS study group. Long-term neurodevelopmental outcome after intrauterine transfusion for hemolytic disease of the fetus/newborn: the LOTUS study. Am J Obstet Gynecol. 2012 Feb;206(2):141.e1-8. Epub 2011 Sep 24. PMID: 22030316

9. von Lindern JS, Hulzebos CV, Bos AF, Brand A, Walther FJ, Lopriore E. Thrombocytopaenia and intraventricular haemorrhage in very premature infants: a tale of two cities. Arch Dis Child Fetal Neonatal Ed. 2012 Jan 31. [Epub ahead of print] PMID: 22294474

10. Walther FJ. Reply: Oral Ibuprofen for Patent Ductus Arteriosus - Proof of Concept. Neonatology. 2012 Jul 7;102(3):196A. [Epub ahead of print] PMID: 22777064

11. de Waal CG, Weisglas-Kuperus N, van Goudoever JB, Walther FJ, The NeoNed Study Group, The LNF Study Group. Mortality, Neonatal Morbidity and Two Year Follow-Up of Extremely Preterm Infants Born in the Netherlands in 2007. PLoS One. 2012;7(7):e41302. Epub 2012 Jul 23. PMID: 22911776

12. Lopriore E, Sluimers C, Pasman SA, Middeldorp JM, Oepkes D, Walther FJ. Neonatal Morbidity in Growth-Discordant Monochorionic Twins: Comparison Between the Larger and the Smaller Twin. Twin Res Hum Genet 2012 Aug; 15(4): 541-6. PMID: 22854118

13. van der Lugt NM, Lopriore E, Bökenkamp R, Smits-Wintjens VE, Steggerda SJ, Walther FJ. Repeated Courses in Ibuprofen are Effective in Closure of a Patent Ductus Arteriosus. Eur J Pediatr 2012 Aug 5. PMID: 22864766

14. van Klink JM, Koopman HM, van Zwet EW, Oepkes D, Walther FJ, Lopriore E. Cerebral Injury and Neurodevelopmental Impairment after Amnioreduction Versus Laser Surgery in Twin-Twin Transfusion Syndrome: A Systemic Review and Meta-Analysis. Fetal Diagn Ther 2012 Aug 24. PMID: 22922370

15. von Lindern JS, Hulzebos CV, Bos AF, Brand A, Walther FJ, Lopriore E. Thrombocytopaenia and Intraventricular Haemorrhage in Very Premature Infants: A Tale of Two Cities. Arch Dis Child Fetal Neonatal Ed 2012 Sep;97(5):F348-52. PMID: 22933094

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