Harbor-UCLA Pediatrics

Eduard H. Panosyan, M.D.
Assistant Clinical Professor of Pediatrics
Division of Pediatric Hematology and Oncology

Contact Information:
1000 W. Carson St.
Bldg N-25 Box 468
Torrance, CA 90509

Phone: (310) 222-4154
Fax: (310) 320-2271
Email: epanosyan@labiomed.org

Research Focus:
My research interests are on signaling pathways and related cellular mechanisms by which stem cell-like cells from pediatric brain tumors may give rise to multi-passageable oncospheres in vitro, which are tumorigenic in vivo. This knowledge will help to fuel the research to understand the potentially variable response of pediatric brain tumors to different inhibitors of relevant signaling pathways. One of my specific goals is to create cellular resources with oncosphere cultures from pediatric brain tumors that can be utilized as pre-clinical model for developmental therapeutics.

Certifications:
American Board of Pediatrics, General Pediatrics

Training:
Residency in Pediatrics, Pediatric Oncology, Armenia
Post-Doctoral Fellowship, Children’s Hospital Los Angeles
Internship and Residency in Pediatrics, MLK Medical Center, LA
Residency in Pediatrics, Loma Linda University Medical Center, CA
Fellowship in Pediatric Hematology/Oncology, UCLA
Chief Fellow, Pediatric Hematology/Oncology, UCLA

Education:
M.D., Yerevan State Medical University, Armenia

Selected Publications:

1. Grigoryan RS, Panosyan EH, Seibel NL, Gaynon PS, Avramis IA, Avramis VI. Changes of amino acid serum levels in pediatric patients with higher-risk acute lymphoblastic leukemia (CCG-1961). In Vivo. 2004 Mar-Apr;18(2):107-12. PMID: 15113036.

2. Panosyan EH, Grigoryan RS, Avramis IA, Seibel NL, Gaynon PS, Siegel SE, Fingert HJ, Avramis VI. Deamination of glutamine is a prerequisite for optimal asparagine deamination by asparaginases in vivo (CCG-1961). Anticancer Res. 2004 Mar-Apr;24(2C):1121-5. PMID: 15154634.

3. Panosyan EH, Seibel NL, Martin-Aragon S, Gaynon PS, Avramis IA, Sather H, Franklin J, Nachman J, Ettinger LJ, La M, Steinherz P, Cohen LJ, Siegel SE, Avramis VI. Asparaginase antibody and asparaginase activity in children with higher-risk acute lymphoblastic leukemia: Children's Cancer Group Study CCG-1961. J Pediatr Hematol Oncol. 2004 Apr;26(4):217-26. PMID: 15087948.

4. Hawkins DS, Park JR, Thomson BG, Felgenhauer JL, Holcenberg JS, Panosyan EH, Avramis VI. Asparaginase pharmacokinetics after intensive polyethylene glycol-conjugated L-asparaginase therapy for children with relapsed acute lymphoblastic leukemia. Clin Cancer Res. 2004 Aug 15;10(16):5335-41. PMID: 15328169.

5. Avramis VI, Panosyan EH. Pharmacokinetic/pharmacodynamic relationships of asparaginase formulations: the past, the present and recommendations for the future. Clin Pharmacokinet. 2005;44(4):367-93. Review. PMID: 15828851.

6. Avramis IA, Panosyan EH, Dorey F, Holcenberg JS, Avramis VI; Children's Oncology Group. Correlation between high vascular endothelial growth factor-A serum levels and treatment outcome in patients with standard-risk acute lymphoblastic leukemia: a report from Children's Oncology Group Study CCG-1962. Clin Cancer Res. 2006 Dec 1;12(23):6978-84. PMID: 17145817.

7. Sun J, Masterman-Smith MD, Graham NA, Jiao J, Mottahedeh J, Laks DR, Ohashi M, Dejesus J, Kamei K, Lee KB, Wang H, Yu ZT, Lu YT, Hou S, Li K, Liu M, Zhang N, Wang S, Angenieux B, Panosyan E, Samuels ER, Park J, Williams D, Konkankit V, Nathanson D, van Dam RM, Phelps ME, Wu H, Liau LM, Mischel PS, Lazareff JA, Kornblum HI, Yong WH, Graeber TG, Tseng HR. A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens, Cancer Res. 2010 Aug 1;70(15):6128-38. Epub 2010 Jul 14. PMID: 20631065.

8. Panosyan EH, Laks DR Masterman-Smith M, Mottahedeh J, Yong WH, Cloughesy TF, Lazareff JA, Mischel PS, Moore TB, Kornblum HI. Clinical Outcome in Pediatric Glial and Embryonal Brain Tumors Correlates with In Vitro Multi-passageable Neurosphere Formation, Pediatr Blood Cancer. 2010 Oct;55(4):644-51. PMID: 20589659.

9. Panosyan EH, Ikeda AK, Chang V, et al. High-Dose Chemotherapy with Autologous Hematopoietic Stem-Cell Rescue (AHSCR) for Pediatric Brain Tumor Patients, a single institution experience from UCLA. J Transplant. 2011:740673. Epub 2011 Apr 14. PMID: 21559259

10. Visnyei K, Onodera H, …Panosyan E, et al. A molecular screening approach to identify and characterize inhibitors of glioblastoma multiforme stem cells. Mol Cancer Ther. 2011 Oct;10(10):1818-28. Epub 2011 Aug 22. PMID: 21859839

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