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Basil O. Ibe, Ph.D.

Basil Ibe, MD

Basil O. Ibe, Ph.D.
Professor of Pediatrics
Division of Neonatology
Director, Summer Fellowship Program

Contact Information:
Walter P. Martin Research Center
1124 West Carson St., RB-1
Torrance, CA 90502

Phone: (310) 222-1966
Fax: (310) 222-3887
Email: ibe@labiomed.org

Research Focus:
Dr. Ibe is Professor of Pediatrics and has been a member of the department since 1988 when he joined the faculty in the Division of Neonatology. He has been conducting research in perinatal pulmonary biochemistry. In his Masters’ degree work, Dr. Ibe performed chemical synthesis of potential anticonvulsant agents based on their structure-activity relationships. In his doctoral work, he performed chemical synthesis and pharmacological evaluation of potential anticholinergic agents based on their structure-activity relationships and molecular-electronic properties.

In the past twenty years, his work has focused on understanding the factors that facilitate the perinatal pulmonary adaptation, focusing primary on the role of platelet activating factor (PAF) and eicosanoids in perinatal pulmonary adaptation; and the role of PAF in the pathology of persistent pulmonary hypertension of the newborn. He also investigates the role of endogenous lipid mediators (PAF and eicosanoids) in cardiovascular and pulmonary abnormalities of sickle cell disease. His research employs small, medium and large animal models as well cell culture to study factors that promote favorable perinatal pulmonary adaptation. His work includess investigations in the role of NF-kB, intracellular kinases and retinoblastoma protein in the regulation of PAF receptor gene and protein expression, and the study of the role of PAF and NF-kB in airway inflammation in asthma. He has published 42 articles and 69 abstracts in these areas since 1987.

Dr. Ibe is the Director of the Summer Fellowship Program at the Los Angeles Biomedical Research Institute and the Director of the Cell and Tissue Culture Facility at the Walter P. Martin Research Building. He is a member of the American Physiological Society, the American Society for Pharmacology and Experimental Therapeutics, the Association of African Biomedical Scientists of which he is the Vice President, and the American Federation of Teachers. He is a reviewer for American Journal of Physiology Cell Molecular Physiology, International Archives of Allergy and Immunology, Journal of Pharmacology and Experimental Therapeutics, British Journal of Pharmacology and Journal of Laboratory and Clinical Medicine. Dr. Ibe guides fellows in basic science research in pulmonary biochemistry. He serves as a mentor to students aspiring to graduate and professional schools in the sciences and health care fields.

Training:
Postdoctoral Fellowship in Cardiovascular Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas (laboratory of Dr. William B. Campbell)
Postdoctoral Fellowship in Pulmonary Toxicology, Molecular Toxicology and Environmental Health Sciences Program, School of Pharmacy, University of Colorado, Boulder, Colorado (laboratory of Dr. John Thompson)

Education:
Ph.D., Pharmacy, The University of Texas at Austin, Austin, Texas
M.S., Pharmacy, Idaho State University, Pocatello, Idaho
B.S., Pepperdine University, Los Angeles, California

Selected Publications:

1. Ibe BO, Raj JU. Endogenous arachidonic acid metabolism by calcium ionophore stimulated Ferret lungs: Effect of age, hypoxia, Lab Invest. 66:370-377, 1992.

2. Ibe BO, Kurantsin-Mills J, Raj JU, Lessin LS. Plasma and urinary leukotrienes in sickle cell disease: possible role in the inflammatory process. Eur J Clin Invest vol 24:57-64, 1994.

3. Oh SO, Ibe BO, Johnson C, Kurantsin-Mills J, Raj JU. Platelet activating factor in plasma of sickle cell disease patients in steady state. J Lab Clin Med, 130:191-196, 1997.

4. Ibe BO, Hibler S, Raj JU. Platelet activating factor modulates pulmonary vasomotor tone in the perinatal lamb. J Appl Physiol, 85:1079-1085, 1998.

5. Ibe BO, Sander FC, Raj JU. Platelet activating factor acetylhydrolase activity in lamb lungs is up-regulated in the immediate newborn period. Mol Genet Met. 69:46-55, 2000.

6. Ibe BO, Sander FC, Raj JU. Platelet activating factor receptors in lamb lungs are down-regulated immediately after birth. Am J Physiol Heart Circ Physiol. 278:H1168-H1176, 2000.

7. Ibe BO, Portugal AM, Raj JU. Metabolism of platelet activating factor by intrapulmonary vascular smooth muscle cells. Effect of oxygen on phospholipase A2 protein expression and activities of acetyl-CoA acetyltransferase and cholinephosphotransferase. Mol Genet Metab 77:237-248, 2002

8. Ibe BO, Portugal AM, Chaturvedi S, Raj JU. Oxygen-dependent PAF-receptor binding and intracellular signaling in ovine fetal pulmonary vascular smooth muscle. Am J Physiol Lung Cell Mol Physiol. 288: L879-886, 2005

9. John TA, Ibe BO, Raj JU. Oxygen alters caveolin-1 and nitric oxide synthase-3 functions in ovine fetal and neonatal lung microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol. 291: L1079-L1093, 2006.

10. Zhou W, Ibe BO, Raj JU. Platelet activating factor induces ovine fetal pulmonary venous smooth muscle cell proliferation: Role of epidermal growth factor receptor transactivation. Am J Physiol Heart Circ Physiol. 292: H2773-H2781, 2007.

11. Bixby CE, Ibe BO, Abdallah MF, Zhou W Hislop AA, Longo LD Raj JU. Role of platelet Activating factor in pulmonary vascular remodeling associated with chronic high-altitude hypoxia in ovine fetal lambs. Am J Physiol Lung Cell Mol Physiol 239:L1475-1482, 2007.

12. Ibe BO, Abdallah MF, Raj JU. Mechanisms by which (S)-albuterol induces human bronchial smooth muscle cell proliferation. Int Arch Allergy Immunol 146:321-333, 2008.

13. Sheng L, Zhou W, Hislop AA, Ibe BO, Longo LD, Raj JU. Role of epidermal growth factor receptor in ovine fetal pulmonary vascular remodeling following exposure to high altitude long- term hypoxia. High Alt Med Biol 10:365-372, 2009.

14. Renteria LS, Raj JU, Ibe BO. Prolonged hypoxia modulates platelet activating factor receptor-mediated responses by fetal ovine pulmonary vascular smooth muscle cells. Mol Genet Metab. 2010 Dec;101(4):400-8. Epub 2010 Aug 10. PMID: 20813571

15. Bae R, Arteaga A, Raj JU, Ibe BO. Albuterol Isomers Modulate Platelet-Activating Factor Synthesis and Receptor Signaling in Human Bronchial Smooth Muscle Cells. Int Arch Allergy Immunol. 2011 Dec 28;158(1):18-26. PMID: 22212397

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