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Agnes Chen, M.D.

Agnes Chen, MD

Agnes Chen, M.D.
Associate Professor of Pediatrics and Neurology
Division of Neurology

Contact Information:
1000 W. Carson St.
Box 468
Torrance, CA 90502

Phone: (310) 222-4160
Email: ahchen@ucla.edu

Research Focus:
Central nervous system disease in the mucopolysaccharidoses and other lysosomal storage disorders. Intrathecal enzyme replacement therapy for mucopolysaccharidosis I.

American Board of Pediatrics, General Pediatrics
American Board of Psychiatry and Neurology, Neurology with Special Qualification in Child Neurology

Internship and Residency in Pediatrics, Harbor-UCLA Medical Center/UCLA, Torrance, CA
Residency in Adult and Child Neurology, Harbor-UCLA Medical Center/UCLA, Torrance, CA

M.D., Boston University School of Medicine, Boston, MA
A.B., Biology, Harvard University, Cambridge, MA

Selected publications and abstracts:

1. R Ackerman, G Gahn, K Barrett, A Huang, D Liu, I Huang, A Brown, M Candia, Relevance of Transcranial Doppler Studies of Cerebrovascular Reserve, Poster presentation at the 49th Annual Meeting of the American Academy of Neurology, Boston, MA, 1997

2. R Ackerman, K Barrett, M Candia, G Gahn, L Marvel, A Huang, D Liu, Hemodynamic significance of ophthalmic flow reversal, Poster presentation at the 23rd International Joint Conference on Stroke and Cerebral Circulation, Orlando FL, 1998

3. Gahn G, Ackerman RH, Candia MR, Barrett KM, Lev MH, Huang AY. Dodecafluoropentane ultrasonic contrast enhancement in carotid diagnosis: preliminary results. J Ultrasound Med. 1999 Feb;18(2):101-8. PMID: 10206802

4. Dickson PI, Hanson S, McEntee MF, Vite CH, Vogler CA, Mlikotic A, Chen AH, Ponder KP, Haskins ME, Tippin BL, Le SQ, Passage MB, Guerra C, Dierenfeld A, Jens J, Snella E, Kan SH, Ellinwood NM. Early versus late treatment of spinal cord compression with long-term intrathecal enzyme replacement therapy in canine mucopolysaccharidosis type I. Mol Genet Metab. 2010 Oct-Nov;101(2-3):115-22. Epub 2010 Jul 23. PMID: 20655780

5. Dierenfeld AD, McEntee MF, Vogler CA, Vite CH, Chen AH, Passage M, Le S, Shah S, Jens JK, Snella EM, Kline KL, Parkes JD, Ware WA, Moran LE, Fales-Williams AJ, Wengert JA, Whitley RD, Betts DM, Boal AM, Riedesel EA, Gross W, Ellinwood NM, Dickson PI. Replacing the enzyme alpha-L-iduronidase at birth ameliorates symptoms in the brain and periphery of dogs with mucopolysaccharidosis type I. Sci Transl Med. 2010 Dec 1;2(60):60ra89. PMID: 21123810

6. A Chen, Vogler C, McEntee M, Hanson S, Ellinwood NM, Jens J, Snella E, Passage M, Le S, Guerra C, Dickson P. Glycosaminoglycan storage in neuroanatomical regions of mucopolysaccharidosis I dogs following intrathecal recombinant human iduronidase. APMIS. 2011 Aug;119(8):513-21. doi:10.1111/j.1600-0463.2011.02760.x. Epub 2011 May 14. PMID: 21749451

7. A Chen, Dickson P. Intrathecal enzyme replacement therapy to treat spinal cord
compression in mucopolysaccharidosis: Overview and rationale. J Pediatr Rehabil Med. 2010;3(1):7-11. PMID: 21791827

8. Dickson PI, Chen AH. Intrathecal enzyme replacement therapy for mucopolysaccharidosis I: translating success in animal models to patients. Curr Pharm Biotechnol. 2011 Jun;12(6):946-55. doi: 1389-2010/11 $58.00+.00. Review. PMID: 21506913

9. Chen AH, Dickson PI. Enzyme replacement therapy for cognitive decline in MPS I: past, present and future. Curr Med Lit—Lysosomal Storage Diseases 9:9-16, 2011.

10. Chen AH. Update on pediatric epilepsy. Adv Pediatr. 2011;58(1):259-76. Review. PMID: 21736985

Pubmed Search:
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