Brigette L. Tippin, Ph.D.

Brigette L. Tippin, Ph.D.
Clinical Instructor of Pediatrics
Division of Medical Genetics

Certifications
American Board of Medical Genetics, Clinical Molecular Genetics 2007

Experience and Professional Training:
1992-1996 BS Biological Sciences, University of Southern California, Los Angeles
1996-2004, PhD Molecular Biology, University of Southern California, Los Angeles
2004-2006, NIH Post-Doctoral Fellow, UCLA Intercampus Medical Genetics Training Program

Research Interests:
My research interests are focused on using molecular techniques to design new therapeutics for rare-genetic disorders. Ongoing projects include development of tumor-suppressive agents for an inherited form of colon cancer and new enzyme replacement therapies to treat the brain in lysosomal storage diseases. In addition, I have a long standing interest in mechanisms of error-prone DNA repair that lead to permanent genetic mutations.

Selected Publications:
1. Goodman MF, Tippin B. Sloppier copier DNA polymerases involved in genome repair. Curr Opin Genet Dev. 2000 Apr;10(2):162-8. Review.

2. Goodman MF, Tippin B. The expanding polymerase universe. Nat Rev Mol Cell Biol. 2000 Nov;1(2):101-9. Review.

3. Tippin B, Goodman MF. A new class of errant DNA polymerases provides candidates for somatic hypermutation. Philos Trans R Soc Lond B Biol Sci. 2001 Jan 29;356(1405):47-51. Review.

4. Poltoratsky V, Woo CJ, Tippin B, Martin A, Goodman MF, Scharff MD. Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation. Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7976-81.

5. Tippin B, Pham P, Goodman MF. Error-prone replication for better or worse. Trends Microbiol. 2004 Jun;12(6):288-95. Review.

6. Tippin B, Kobayashi S, Bertram JG, Goodman MF. To slip or skip, visualizing frameshift mutation dynamics for error-prone DNA polymerases. J Biol Chem. 2004 Oct 29;279(44):45360-8.

7. Ma Y, Lu H, Tippin B, Goodman MF, Shimazaki N, Koiwai O, Hsieh CL, Schwarz K, Lieber MR. A biochemically defined system for mammalian nonhomologous DNA end joining. Mol Cell. 2004 Dec 3;16 (5):701-13.

8. Tippin B, Pham P, Bransteitter R, Goodman MF. Somatic hypermutation: a mutational panacea. Adv Protein Chem. 2004;69:307-35.

9. Park JM, Kanaoka Y, Eguchi N, Aritake K, Grujic S, Materi AM, Buslon VS, Tippin BL, Kwong AM, Salido E, French SW, Urade Y,Lin HJ. Hematopoietic Prostaglandin D Synthase Suppresses Intestinal Adenomas in ApcMin/+ Mice. Cancer Res. 2007 Feb 1;67(3):881-9.

10. Gu J, Lu H, Tippin B, Goodman MF, Lieber MR. XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps. EMBO J. 2007 Feb 21;26(4):1010-23.